Endocrine Abstracts

Introduction: The prevalence of Transgender individuals seeking gender affirming hormone therapy (GAHT) has been increasing. It is important to closely monitor this therapy in order to minimize the risk of adverse effects.Aim: To evaluate the safety and monitoring of the GAHT in the Portuguese adult transgender populationMethods: Cross-sectional study conducted in March 2021. Data collected through an online questionnaire ...

Background: Post surgery hypocalcemia is the most common sequel of thyroidectomy. An accurate prediction of hypocalcemia in the immediate postoperative period would enable the selection of patients for appropriate treatment and facilitate early discharge. Objective: This study aims to investigate the prevalence of hypocalcemia after thyroidectomy and to identify potential risk factors. Methods: This is a retrospective cohort study ...

A major limitation of nutritional science is the objective assessment of dietary intake in free-living populations. Monitoring individuals’ response to policy recommendations is based on self-reported dietary assessment tools, which are known to have high misreporting rates estimated at 30–88%. We have developed a novel analytical pipeline capable to classify people into consumers of a healthy or unhealthy diet based on urinary metabolic patterns, without relying on ...

High protein diets are highly satiating but hard to maintain. By understanding the mechanisms underlying these effects we may be able to identify new anti-obesity therapies. Protein is broken-down into amino acids in the gut which are detected by a series of nutrient sensors. The calcium sensing receptor (CaSR) is primarily activated by calcium ions, but is positively allosterically modulated by aromatic amino acids, especially L-phenylalanine. Sti...

A major limitation of nutritional science is the objective assessment of dietary intake in free-living populations. Monitoring individuals’ response to policy recommendations is based on self-reported dietary assessment tools, which are known to have high misreporting rates estimated at 30–88%. We have developed a novel analytical pipeline capable to classify people into consumers of a healthy or unhealthy diet based on urinary metabolic patterns, without relying on ...

High protein diets are highly satiating but hard to maintain. By understanding the mechanisms underlying these effects we may be able to identify new anti-obesity therapies. Protein is broken-down into amino acids in the gut which are detected by a series of nutrient sensors. The calcium sensing receptor (CaSR) is primarily activated by calcium ions, but is positively allosterically modulated by aromatic amino acids, especially L-phenylalanine. Sti...

Thyroid hormone resistance syndrome(THRS) occurs in 1:40000 live births and can be diagnosed after a period of enigmatic changes in thyroid hormones(TH). Patients may be clinically euthyroid, have clinical hypo or hyperthyroidism. Mostly, it is an autosomal dominant disease due to germline mutations in THRβ-gene(exons 7-10). Resistance to peripheral action of TH leads to absence of TSH suppression (which can be normal/elevated) despite elevated fT4 and fT3.<p class="a...

Introduction: Testosterone-based gender-affirming hormone therapy (GAHT) may have negative consequences on cardiovascular risk, with reported increased blood pressure, decreased HDL-cholesterol, and weight gain. Still, data on cardiometabolic changes in transgender men on GAHT remain controversial. Testosterone-based GAHT also modifies body composition and lean muscle mass, but the degree to which affects serum creatinine and other measures of kidney function is still not clea...

Introduction: Parathyroid carcinoma (PC) is an extremely rare malignancy. A complete surgical excision is often difficult, and persistent/recurrent disease occurs in up to 65% of cases. Progression often leads to symptomatic hypercalcemia, the major contributor to poor quality of life and mortality. Treatment options beyond surgical resection are limited. Denosumab is an approved therapy for refractory hypercalcemia of malignancy, and its use in unresectable PC has been descri...

Introduction: Adrenocortical carcinoma (ACC) is one of the most aggressive endocrine malignancies and confers a poor prognosis in advanced stages. Effective treatments are lacking. The results of immune checkpoint inhibition were disappointing with few responders only deriving clinical benefit. For the development of novel immunotherapies such as tumor vaccines and T cell-based treatments, target identification is essential. Tumor-specific mutant neoantigens that may be recogn...